Kidney Injury, Insulin Therapy, and Hypoglycemia

نویسنده

  • Roland N. Dickerson
چکیده

The intent of this review is to evaluate the literature with respect to increased risk for hypoglycemia for critically ill patients with acute kidney injury or chronic kidney disease who are given insulin therapy. The unique pathophysiology of insulin and glucose metabolism during renal failure that predisposes patients for hypoglycemia is reviewed. Studies that contribute to the understanding and clinical relevance of renal dysfunction upon glycemic control during intensive insulin and continuous nutrition therapy are evaluated. Some practical suggestions for management of hyperglycemia with insulin therapy for critically ill patients with renal failure are given.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Regulation of Intestinal GLP-1 and GLUT2 genes underlie hypoglycemia in Desplatsia subericarpa (Bocq)-Fed Wistar Rats

Background & Aim:Indigenous people of West Africa use the whole-leaf of Desplatsia subericarpa (Bocq) in anti-diabetic soup delicacy. This study was designed to validate the anti-diabetic claims and delineating possible mechanisms. Experimental:RT-PCR method was used to investigate regulation of intestinal glucose transporter 2 (GLUT2) and glucag...

متن کامل

Regulation of Intestinal GLP-1 and GLUT2 genes underlie hypoglycemia in Desplatsia subericarpa (Bocq)-Fed Wistar Rats

Background & Aim:Indigenous people of West Africa use the whole-leaf of Desplatsia subericarpa (Bocq) in anti-diabetic soup delicacy. This study was designed to validate the anti-diabetic claims and delineating possible mechanisms. Experimental:RT-PCR method was used to investigate regulation of intestinal glucose transporter 2 (GLUT2) and glucag...

متن کامل

Impact of glycemic control on the incidence of acute kidney injury in critically ill patients: a comparison of two strategies using the RIFLE criteria

OBJECTIVE To compare the renal outcome in patients submitted to two different regimens of glycemic control, using the RIFLE criteria to define acute kidney injury. INTRODUCTION The impact of intensive insulin therapy on renal function outcome is controversial. The lack of a criterion for AKI definition may play a role on that. METHODS Included as the subjects were 228 randomly selected, cri...

متن کامل

Development and validation of a prediction model for insulin-associated hypoglycemia in non-critically ill hospitalized adults

Objective To develop and validate a multivariable prediction model for insulin-associated hypoglycemia in non-critically ill hospitalized adults. Research design and methods We collected pharmacologic, demographic, laboratory, and diagnostic data from 128 657 inpatient days in which at least 1 unit of subcutaneous insulin was administered in the absence of intravenous insulin, total parentera...

متن کامل

Predisposing Factors for Hypoglycemia and Its Relation With Mortality in Critically Ill Patients Undergoing Insulin Therapy in an Intensive Care Unit

BACKGROUND Hypoglycemia is a common and the most important complication of intensive insulin therapy in critically ill patients. Because of hypoglycemia's impact on the cardinal organs as a fuel, if untreated it could results in permanent brain damage and increased mortality. OBJECTIVES In this study, we aim to evaluate the incidence of hypoglycemia, its risk factors, and its relationship wit...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2012